苟明月,教授,博士生导师。现任英国上市公司官网365作物基因组学与分子育种中心主任、国家玉米改良(郑州)分中心副主任。在中国农业大学获得博士学位,先后在美国康奈尔大学和布鲁海文国家实验室从事多年植物抗病和细胞壁合成机制研究工作。发现
CPR30/
CPR1、
SIZ1、
BON1、
HSC70、
ZmBON1等基因调控植物抗病防御反应及生长发育的新机制;阐明了
MSBP、
CB5D、
KFB、
MYB107、
ZmKCS12等基因介导细胞壁(木质素、木栓质、蜡质)合成新机制;现主持国家自然科学基金联合基金重点项目、面上项目、国家重点研发专项课题等科研项目,主要开展玉米抗病(逆)机制研究与分子育种工作,在玉米广谱抗病性及抗倒伏性研究中取得重要进展。在Nature Plants、Nature communications、Plant Cell、EMBO Journal、Journal of Integrative Plant Biology、Plant Journal、Plant Physiology、Journal of Experimental Botany、The Crop Journal等期刊发表论文30余篇,论文被引用2000余次。担任Frontiers in Plant Science期刊副主编及Nature Genetics、Plant Cell等期刊审稿人。入选中原基础研究领军人才、河南省特聘教授、河南省杰青、中原青年拔尖人才、河南省高层次人才。
联系方式:
电话:0371-56990319
邮箱:
mingyuegou@henau.edu.cn
地址:郑州市郑东新区平安大道218号英国上市公司官网365龙子湖校区第一实验楼南405
网页:
https://www.researchgate.net/profile/Mingyue-Gou
https://scholar.google.com/citations?user=0jFPU1IAAAAJ&hl=en(谷歌学术)
教育与研究/工作经历:
2017年-至今 英国上市公司官网365教授,河南省特聘教授;
2012-2018年 美国布鲁克海文国家实验室生物系,副研究员(Research Associate);
2009-2012年 美国康奈尔大学植物系,博士后;
2003-2009年 中国农业大学生物学院,理学博士学位;
1999-2003年 西南农业大学(现西南大学)英国上市公司官网365,农学学士学位。
研究方向:
植物/作物抗病(逆)机制研究与分子育种
主要研究内容:
1、玉米抗病基因挖掘与分子机制解析;
2、玉米抗倒伏基因挖掘与分子机制解析;
3、植物细胞壁(木质素、木栓质、蜡质)合成机制研究;
4、植物生长与抗病平衡机理研究;
5、玉米基因编辑及分子育种。
主要荣誉:
1、2017年度河南省特聘教授;
2、2019年“中原千人计划”-中原青年拔尖人才;
3、2020年河南省高层次人才;
4、2021年河南省杰出青年科学基金获得者;
5、2021年“挑战杯”河南省大学生课外学术科技作品竞赛二等奖指导教师;
6、2022年河南省大学生微生物实验设计大赛二等奖指导教师;
7、2022年度英国上市公司官网365本科优秀毕业论文指导教师;
8、2022年度英国上市公司官网365优秀教师;
9、2023年“挑战杯”河南省大学生课外学术科技作品竞赛一等奖指导教师;
10、2023年中原基础研究领军人才。
研究项目:
1、国家自然科学基金联合基金重点项目:黄淮地区玉米叶部病害广谱抗病基因克隆与广谱抗性机制解析(U2004207),2021-2024,主持人
2、国家自然科学基金面上项目:玉米四跨膜蛋白ZmTET1介导南方锈病和弯孢叶斑病抗性分子机制研究(32372208),2024-2027,主持人
3、国家重点研发专项:“玉米宜籽粒机收抗逆高产基因资源挖掘与利用”项目“玉米适宜籽粒机收关键基因位点挖掘与应用”课题(2023YFD1200501),2023-2027,课题负责人
4、国家重点研发专项:“玉米抗病虫高产基因资源挖掘与利用”项目“玉米抗病虫高产基因的生物育种应用”课题(2022YFD1201801),2022-2027,子课题负责人
5、2023年度中原英才计划(育人系列)-中原基础研究领军人才项目,主持人
6、河南省杰出青年科学基金项目:BLES10 调控玉米广谱抗病性机制解析及其育种应用(212300410007), 2021-2023,主持人
7、“中原千人计划”中原青年拔尖人才项目:作物抗病与细胞壁合成机制研究(ZYQR201912168),2020-2022,主持人
8、河南省重大科技专项:玉米关键性状优异基因挖掘与新品种选育(221100110300),2022-2024,参与
9、美国能源部(DOE)专项,Metabolic plasticity, macromolecular organization, and post-translational regulation of lignin biosynthesis (DE-SC0012704),2012 -2020,参与
10、美国国家自然科学基金(NSF)项目,Molecular mechanisms underlying temperature modulation of defense responses (0919914), 2009 -2013,参与
11、美国国家自然科学基金(NSF)项目, Regulation of a resistance gene by BON1 in Arabidopsis (0642289), 2007 -2010,参与
12、国家高技术研究发展计划(863计划)项目:玉米抗旱性形成的遗传调控研究(2006AA10Z103),2006-2010,参与
讲授课程:
作物抗病与抗逆生物学、植物生物技术、分子生物学、农业微生物学。
发表论文:
1. Teng Jing, Yuying Wu, Yanwen Yu, Jiankun Li, Xiaohuan Mu, Liping Xu, Xi Wang, Guang Qi, Jihua Tang, Daowen Wang, Shuhua Yang, Jian Hua,
Mingyue Gou* (
2024). Copine proteins are required for brassinosteroid signaling in maize and Arabidopsis.
Nature Communications, in press. (IF=16.6)
2. Liping Xu, Jiaxin Hao, Mengfan Lv, Peipei Liu, Qidong Ge, Sainan Zhang, Jianping Yang, Hongbin Niu, Yiru Wang, Yadong Xue, XiaoDuo Lu, Jihua Tang, Jun Zheng* and
Mingyue Gou* (
2024). A genome-wide association study identifies new genes associating with cuticular wax metabolism in maize.
Plant Physiology, kiae007. (IF=7.4)
3. Jiankun Li., Tianyuan Fan, Ying Zhang, Ye Xing, Mengyao Chen, Ying Wang, Jie Gao, Na Zhang, Jinjun Tian, Chenyang Zhao, Sihan Zhen, Junjie Fu, Xiaohuan Mu, Jihua Tang, Hongbin Niu* and
Mingyue Gou* (
2024). Characterization and fine mapping of a maize lesion mimic mutant (Les8) with enhanced resistance to Curvularia leaf spot and southern leaf blight.
Theoretical Applied Genetics 137, 7. (IF=5.4)
4. Mingyue Gou, Peter Balint-Kurti, Mingliang Xu, and Qin Yang (
2023). Quantitative disease resistance: Multifaceted players in plant defense.
Journal of Integrative Plant Biology, 65: 594-610. (IF =11.4
)
5. Xianhai Zhao, Yunjun Zhao,
Mingyue Gou, and Chang-Jun Liu* (
2023). Tissue-preferential recruitment of electron transfer chains for cytochrome P450-catalyzed phenolic biosynthesis.
Science advances, 9: eade4389. (IF
=13.6
)
6. Huaibing Jin, Xinyun Han, Zhaohui Wang, Yilin Xie, Kunpu Zhang, Xiaoge Zhao, Lina Wang, Jin Yang, Huiyun Liu, Xiang Ji, Lingli Dong, Hongyuan Zheng, Weijuan Hu, Yan Liu, Xifeng Wang, Xueping Zhou, Yijing Zhang, Weiqiang Qian, Wenming Zheng, Qianhua Shen*,
Mingyue Gou*, Daowen Wang* (
2022). Barley GRIK1-SnRK1 kinases subvert a viral virulence protein to upregulate antiviral RNAi and inhibit infection.
The EMBO Journal, 41: e110521.(IF= 11.4)
【Recommended by You et al., (2022) Achieving a more robust antiviral RNAi via subverting a viral virulence protein.
Molecular Plant, 15: 1514-1516】
7.Jiankun Li, Mengyao Chen, Tianyuan Fan, Xiaohuan Mu, Jie Gao, Ying Wang, Teng Jing, Cuilan Shi, Hongbin Niu, Sihan Zhen, Junjie Fu, Jun Zheng, Guoying Wang, Jihua Tang,
Mingyue Gou* (
2022). Underlying mechanism of accelerated cell death and multiple disease resistance in a maize lethal leaf spot 1 allele.
Journal of Experimental Botany, 73: 3991-4007.(IF=6.9)
8. Yanwen Yu, Tongxiang Zhang, Jinfan Sun, Teng Jing, Yanjie Shen, Kunpu Zhang, Yan Chen, Dong Ding, Guoying Wang, Jianping Yang, Jihua Tang, Zhenying Shi*, Daowen Wang*,
Mingyue Gou * (
2022). Evolutionary characterization of miR396s in Poaceae exemplified by their genetic effects in wheat and maize.
Plant Science 325:111465.(IF=5.2)
9. Guanghua Sun, Luhao Yang, Weimin Zhan, Shizhan Chen, Meifang Song, Lijian Wang, Liangliang Jiang, Lin Guo, Ke Wang, Xingguo Ye,
Mingyue Gou, Xu Zheng, Jianping Yang*, Zehong Yan* (
2022). HFR1, a bHLH transcriptional regulator from Arabidopsis thaliana, improves grain yield, shade and osmotic stress tolerances in common wheat.
International Journal of Molecular Sciences, 23(19):12057. (IF =5.6
)
10. Xiaohuan Mu
#, Zhuangzhuang Dai
#, Zhanyong Guo, Hui Zhang, Jianping Yang, Xinke Gan, Jiankun Li, Zonghua Liu, Jihua Tang*,
Mingyue Gou* (
2022). Systematic dissection of disease resistance to southern corn rust by bulked-segregant and transcriptome analysis.
The Crop Journal, 10(2): 426-435.(IF=6.6)
11.Xiaohuan Mu
#, Jiankun Li
#, Liping Xu, Zhuangzhuang Dai, Tianyuan Fan, Teng Jing, Mengyao Chen, and
Mingyue Gou* (
2021). Commonly and specifically activated defense responses in maize disease lesion mimics mutants revealed by integrated transcriptomics and metabolomics analysis.
Frontiers in Plant Science, 12:1-19.(IF=5.6)
12. Guangwei Li, Lijian Wang, Jianping Yang*,Hang He, Huaibing Jin, Xuming Li, Tianheng Ren, Zhengnong Ren, Feng Li, Xue Han, Xiaoge Zhao, Lingli Dong, Yiwen Li, Zhongping Song, Zehong Yan, Nannan Zheng, Cuilan Shi, Zhaohui Wang, Shuling Yang, Zijun Xiong, Menglan Zhang, Guanghua Sun, Xu Zheng,
Mingyue Gou, Changmian Ji, Junkai Du, Hongkun Zheng, Jaroslav Doleze, Xing Wang Deng, Nils Stein, Qinghua Yang*, Kunpu Zhang*, Daowen Wang* (
2021). A high-quality genome assembly highlights rye genomic characteristics and agronomically important genes.
Nature Genetics, 53(4):574-584. (IF=30.8)
13. Mingyue Gou#, Xiaoman Yang#, Yunjun Zhao#, Xiuzhi Ran, Yanzhai Song, and Chang-Jun Liu*
(2019). Cytochrome b5 is an obligate electron shuttle protein for syringyl lignin biosynthesis in Arabidopsis. Plant Cell, 31:1344-1366.(IF=11.6)
14. Mingyue Gou, Xiuzhi Ran, Dwight W. Martin and Chang-Jun Liu*
(2018). The scaffold proteins of lignin biosynthetic cytochrome P450 enzymes
. Nature Plants, 4: 299-310.(IF=18.0)
【Recommended by Du et al., (2018) New Components of the Lignin Biosynthetic Metabolon.
Trends in plant science, 23:557-559; and by Wang, B., and Zhao, Q. (2018). Membrane-bound metabolons.
Nature Plants, 4: 245-246.】
15. Dong-Lei Yang, Zhenying Shi, Yongmei Bao, Jiapei Yan, Ziyuan Yang, Huiyun Yu, Yun Li,
Mingyue Gou, Shu Wang, Baohong Zou, Dachao Xu, Zhiqi Ma, Jitae Kim, Jian Hua*
(2017). Calcium pumps and interacting BON1 protein modulate calcium signature, stomatal closure, and plant immunity.
Plant Physiology, 175(1):424-437. (IF=7.4)
16. Mingyue Gou#, Quansheng Huang
#, Weiqiang Qian, Zemin Zhang, Zhenhua Jia, and Jian Hua* (
2017). Sumoylation E3 Ligase SIZ1 modulates plant immunity partly through the immune receptor gene
SNC1 in Arabidopsis.
Molecular Plant-Microbe Interactions, 30(4):334-342. (IF=
3.5)
17. Mingyue Gou, Guichuan Hou, Huijun Yang, Xuebin Zhang, Yuanheng Cai, Guoyin Kai, and Chang-Jun Liu*
(2017).The MYB107 transcription factor positively regulates suberin biosynthesis.
Plant Physiology, 173 (2):1045-1058. (IF=7.4)
18. Mingyue Gou#, Zemin Zhang
#, Ning Zhang
#, Quansheng Huang, Jacqueline Monaghan, Huijun Yang, Zhenying Shi, Cyril Zipfel, and Jian Hua*
(2015). Opposing effects on two phases of defense responses from concerted actions of HEAT SHOCK COGNATE70 and BONZAI1 in Arabidopsis.
Plant Physiology, 169(3):2304-2323. (IF=7.4)
19. Xuebin Zhang,
Mingyue Gou, Chunrong Guo, Huijun Yang, Chang-Jun Liu*
(2014). Down-regulation of the kelch domain-containing F-box protein in Arabidopsis enhances the production of (poly)phenols and tolerance to UV-radiation.
Plant Physiology, 167(2):337-50. (IF=7.4)
20. Chang-Jun Liu*, Yuanheng Cai, Xuebin Zhang,
Mingyue Gou, Huijun Yang
(2014). Tailoring lignin biosynthesis for efficient and sustainable biofuel production.
Plant Biotechnology Journal, 12(9):1154-62. (IF=13.8 )
21. Xiaoqing Wang,
Mingyue Gou, Huahu Bu, Shengxue Zhang, Guoying Wang*
(2014).Proteomic analysis of
Arabidopsis constitutive expresser of pathogenesis-related gene1 (
Cpr30/cpr1-2) mutant.
Plant omics journal, 7(3):123-132
22. Kewei Zhang, Ondrej Novak, Zhaoyang Wei,
Mingyue Gou, Xuebin Zhang, Yong Yu, Huijun Yang, Yuanheng Cai, Miroslav Strnad, and Chang-Jun Liu*
(2014). Arabidopsis ABCG14 protein controls the acropetal translocation of root-synthesized cytokinins.
Nature Communications, 5:3274.(IF=16.6)
23. Xuebin Zhang
#,
Mingyue Gou#, Chang-Jun Liu*
(2013). Kelch repeat F-box proteins regulate phenylpropanoid biosynthesis via controlling the turnover of Phenylalanine Ammonia-Lyase.
Plant Cell, 25: 4994–5010.(IF=11.6)
24. Mingyue Gou and Jian Hua*
(2012). Complex regulation of an
R gene
SNC1 revealed by auto-immune mutants.
Plant Signaling & Behavior, 7(2): 213–216.(IF=2.9)
25. Mingyue Gou, Zhenying Shi, Ying Zhu, Zhilong Bao, Guoying Wang and Jian Hua*
(2012). The F-box protein CPR1/CPR30 negatively regulates R protein SNC1 accumulation.
Plant Journal, 69: 411–420.
(Recommended as top article from F1000's faculty of leading experts).(IF=7.2)
26. Yongqing Li
#,
Mingyue Gou#, Qi Sun, and Jian Hua*
(2010). Requirement of calcium binding, myristoylation, and protein-protein interaction for the copine BON1 function in Arabidopsis.
Journal of Biological Chemistry, 285(39):29884-91.(IF=4.8)
27. Jun Zheng
#, Junjie Fu
#,
Mingyue Gou#, Junling Huai, Yunjun Liu, Min Jian; Quansheng Huang, Xiying Guo, Zhigang Dong, Hongzhi Wang, Guoying Wang*
(2010). Genome-wide transcriptome analysis of two maize inbred lines under drought stress.
Plant Molecular Biology, 72(4-5):407-21.(IF= 5.1)
28. Mingyue Gou#, Nan Su
#, Jun Zheng, Junling Huai, Guangheng Wu, Jinfeng Zhao, Junguang He, Dingzhong Tang, Shuhua Yang, and Guoying Wang*
(2009). An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis.
Plant Journal, 60(5):757-70.(IF= 7.2)
29. Jinfeng Zhao, Zhenfei Sun, Jun Zheng, Xiying Guo, Zhigang Dong, Junling Huai,
Mingyue Gou, Junguang He, Yongsheng Jin, Jianhua Wang, Guoying Wang*
(2009). Cloning and characterization of a novel CBL-interacting protein kinase from maize.
Plant Molecular Biology, 2009, 69:661–674.(IF=5.1)
30. Jun Zheng, Jinfeng Zhao, Jinpeng Zhang, Junjie Fu,
Mingyue Gou, Zhigang Dong, Wei Hou, Jinping Jia, Quansheng Huang and Guoying Wang*
(2006). Comparative expression profiles of maize genes under high-salinity, cold and abscisic acid application using a water stress specific cDNA macroarray.
Plant Science, 170:1125-1132.(IF=5.2)
31. 马文豪,王 盈,葛启栋,陈梦瑶,李见坤*,
苟明月* (2023) 玉米类病斑突变体
Lmm18的表型与初定位分析。玉米科学(已接收).
32. 葛启栋, 张., 郝嘉欣, 马文豪, 吕梦凡, 徐莉萍*,
苟明月* (2023) 天冬氨酸蛋白酶在植物免疫中的研究进展。 植物生理学报 59, 1863-1869.
33. 程相杰、徐莉萍、母小焕、
苟明月*
(2022), 玉米天冬氨酸蛋白酶基因家族的鉴定与表达分析。玉米科学 30 (1):53-62。
34. 白云凤、赵晋锋、郑军、张锦鹏、王茅雁、
苟明月、董志刚、 杨红春、王国英*
(2006),反义外壳蛋白基因介导的抗SCMV转基因玉米研究。 作物学报 32(5):661-665。
35. 白云凤、王国英*、
苟明月、董志刚、赵晋锋
(2006), 农杆菌介导玉米转基因的影响因素研究。中国生态农业学报 14(3):173-175。
注:
#并列第一作者;*通讯(含并列通讯)作者;IF为2022年最新影响因子。
授权专利:
1. 苟明月*、李见坤、王盈、母小焕、徐莉萍、于延文、汤继华、牛洪斌、马文豪(2023), 玉米双调控模块在调控植物生长和抗病平衡中的应用,ZL202210674892.8(国家发明专利)。
2. 苟明月*、荆腾、武玉莹、范田源、李见坤 (2022), 控制玉米株高的基因、其编码的蛋白质以及应用,ZL202011490418.7(国家发明专利)。
学术报告:
1. 国际产学研用合作会议暨第七届黄河国际论坛大会报告:Underlying mechanisms of multiple disease resistance (MDR) revealed by lesion mimic mutants in maize, 2023
2. 第六届全国玉米生物学学术研讨会大会报告:The copine protein controls plant growth via regulating brassinosteroid signaling in maize, 2023
3. 第五届全国玉米抗病学术研讨会大会报告:基于不同类型类病斑突变体解析玉米广谱抗病性机制, 2023
4. 第四届全国玉米抗病学术研讨会大会报告:Commonly activated defense responses in disease lesion mimics mutants and their implication of multiple disease resistance in maize, 2021
5. 植物逆境/棉花生物学国家重点实验室特邀报告: Autoimmunity, lignin biosynthesis and multiple disease resistance in Arabidopsis and maize, 2019
6. 河南省遗传学会年会大会报告:植物自免疫和木质素合成机理研究对解析玉米广谱抗性机制的启示, 2019
7. 中国植物病理学会第十四届青年学术研讨会大会报告:Sophisticated regulation of plant defense response revealed and to be revealed by autoimmune mutants, 2019
8. 第四届全国玉米生物学术研讨会大会报告: Autoimmune mutants: powerful model for maize defense-related studies, 2019
9. 英国上市公司官网365“绍?论坛”特邀报告:植物抗病反应调控及细胞壁合成机理研究, 2018
10. 中国农业大学、中国农业科学院作物所、英国上市公司官网365等高校特邀报告:New insight into plant suberin and lignin biosynthesis, 2016
11. 西北农林科技大学、山东农业大学、四川农业大学、华南植物园等单位特邀报告:植物抗病及细胞壁合成的分子机理, 2016
12. 美国布鲁克海文国家实验室青年科学家论坛(YRS)大会报告:Transcriptional regulation of suberin biosynthesis gene expression, 2015
13. 美国布鲁克海文国家实验室青年科学家论坛(YRS)大会报告:New insight into the metabolon formation of P450s in lignin biosynthesis,2014